{"product_id":"citrullin-plus","title":"Citrulline Plus","description":"\u003ch2\u003e\n\u003cstrong\u003eWhat is Nitric Oxide?\u003c\/strong\u003e \u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eIn 1998, the Nobel Prize in Physiology or Medicine was awarded to American scientists Ignarro, Furchgott and Murad. \u003cstrong\u003eThey discovered and described a gas that is produced and released in blood vessel walls and regulates vessel function: Nitric Oxide, or NO for short.\u003c\/strong\u003e To better understand the effect of NO in the body, one need only think of the famous blue pills for improved performance, which inhibit NO breakdown and thereby stimulate blood circulation. Heart medications work in a similar way, which are based on organic nitrates or nitro-glycerin. Here too, the strongly released Nitric Oxide is intended to dilate the arteries and promote blood circulation.\u003cspan class=\"Apple-converted-space\" data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg style=\"float: none;\" alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0008\/7415\/1991\/files\/NY_Times_Nobelpreis_Ignarro_NO_600x600.png?v=1649937864\"\u003e\u003c\/div\u003e\n\u003cp style=\"text-align: center;\" data-mce-fragment=\"1\"\u003e\u003cem\u003eThe Nobel Prize in Physiology or Medicine was awarded in 1998 to three Americans who discovered NO and described its functions in the body in greater detail. Source: \u003ca href=\"https:\/\/www.nytimes.com\/1998\/10\/13\/us\/three-americans-awarded-nobel-for-discoveries-of-how-a-gas-affects-the-body.html\"\u003eNY Times\u003c\/a\u003e. \u003c\/em\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eNitric Oxide is produced in the endothelial layer of blood vessels and causes dilation or relaxation of smooth vessel muscle. Medical science has published impressive results on NO over the past 10–20 years. \u003cstrong\u003eThus, Nitric Oxide generally promotes vessel health – moreover, a good NO level is a prerequisite for blood vessels to remain healthy at all.\u003c\/strong\u003e A fall in NO levels, which is typically found in the context of Western, that is to say modern lifestyles, causes blood vessels to become dysfunctional, referred to as \u003cem\u003eendothelial or vascular dysfunction \u003c\/em\u003e(\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32172815\/\"\u003eCyr et al. 2020\u003c\/a\u003e)\u003cem\u003e.\u003c\/em\u003e Long-term consequences include arteriosclerosis or other vascular diseases.\u003cspan class=\"Apple-converted-space\" data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eIn recent years, it has additionally been discovered that Nitric Oxide has very, very far-reaching effects on the body. \u003cstrong\u003eThus, it regulates the function of the immune system, and moreover that of cellular energy metabolism.\u003c\/strong\u003e That is, vessel health and general health and in particular the health of energy metabolism are closely linked to one another.\u003cspan class=\"Apple-converted-space\" data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp data-mce-fragment=\"1\"\u003eNitric Oxide (NO) is a signalling molecule that is synthesised in animals by NO synthase from L-Arginine. There is increasing evidence that NO regulates the metabolism of energy substrates in mammals. \u003cbr\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp data-mce-fragment=\"1\"\u003e(\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23553707\/\"\u003eDai et al. 2013\u003c\/a\u003e) \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eNO discoverer and Nobel laureate Louis Ignarro wrote the book „\u003cem\u003eNO More Heart Disease: How Nitric Oxide Can Prevent--Even Reverse--Heart Disease and Strokes\"\u003c\/em\u003e based on these findings and his research. Because: \u003cstrong\u003eNO can be positively influenced by lifestyle factors.\u003c\/strong\u003e Thus, the starting substance for the formation of NO is the amino acid Arginine.\u003c\/p\u003e\n\u003ch2\u003e\n\u003cstrong\u003eWhy Citrulline?\u003c\/strong\u003e \u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eArginine is, however, rapidly metabolised with supplementation. Citrulline, on the other hand, bypasses these effects and increases the arginine level in the blood more strongly than arginine itself. Generally speaking, some substances that can be ingested through food have a positive influence on the modulation of NO levels. \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp data-mce-fragment=\"1\"\u003eL-Citrulline supplementation led to an increase in arginine flux and to a stronger increase in arginine concentration in the plasma than arginine supplementation itself. Whilst citrulline escaped first-pass metabolism, 70% of the supplemented arginine disappeared before it reached the peripheral circulation.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp data-mce-fragment=\"1\"\u003e(\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5368575\/\"\u003eMarini et al. 2017\u003c\/a\u003e) \u003c\/p\u003e\n\u003ch2\u003e\n\u003cstrong\u003eWhat sets edubily®-Citrulline plus apart\u003c\/strong\u003e \u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/h2\u003e\n\u003cp data-mce-fragment=\"1\"\u003eOur product is a delicious, refreshing powder that contains all the necessary cofactors, including Vitamin C from Acerola extract, Citrulline in the well-known malate form (Citrulline malate), Folic acid in two forms (for optimal effect), bioactive Vitamin B12, Glycine, \u003ca href=\"https:\/\/edubily.de\/products\/taurin\"\u003eTaurine\u003c\/a\u003e and the plant compound \u003ca href=\"https:\/\/edubily.de\/products\/granatapfel-extrakt-1\"\u003ePomegranate Extract\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThis premium blend of exciting ingredients not only tastes outstanding, but has been appreciated by thousands of customers for many years – this experience confirms that we have created a unique product here. \u003cbr\u003e\u003c\/p\u003e","brand":"edubily®","offers":[{"title":"Default Title","offer_id":50433116668230,"sku":"EDU-B-004","price":27.5,"currency_code":"CHF","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0855\/4030\/7270\/files\/Citrullin_plus_Frontansicht_1500x1500-250KB.png?v=1726222731","url":"https:\/\/www.edubily.ch\/en\/products\/citrullin-plus","provider":"edubily Schweiz ","version":"1.0","type":"link"}